A 28-year-old laboratory technician at a plague research institute in Siberia died on Friday, October 2, and five days later nobody outside Russia seems to know for certain what killed her. Russian health authorities call the cause “pneumonia of unknown etiology” and say they found no plague in her or in anyone around her. On Tuesday, October 6, the United States pushed harder anyway. President Donald Trump told reporters at the White House that he had a call with Russian President Vladimir Putin on the subject coming “very soon,” Secretary of State Marco Rubio called on Moscow to share more, and the Wall Street Journal reported that the State Department had sent Russia a formal diplomatic warning. Late Tuesday, World Health Organization Director-General Tedros Adhanom Ghebreyesus added a new question: the agency, he said, had asked Russia about media reports of a second employee at the institute with pneumonia of undetermined cause.

The woman worked at the Irkutsk Anti-Plague Research Institute of Siberia and the Far East, founded in 1934 to fight plague and now also tasked with cholera, anthrax, tularemia, brucellosis, and other dangerous diseases, according to its website as cited by NBC News and Healthbeat. Officials have not released her name. Russian media outlets and her mother, NBC reports, identify her as Darya Shipilova. Healthbeat found a “D.N. Shipilova” from the institute listed as a co-author of a study presented this year on how strains of Yersinia pestis, the plague bacterium, respond to antibiotics; it remains unclear whether she worked with the bacteria when she fell ill. Radio Free Europe/Radio Liberty’s Siberia.Realities service reports that she entered the hospital on September 29 and died early on October 2. The independent regional outlet Lyudi Baikala (People of Baikal), as cited by Healthbeat, places her death on the evening of October 2, and the Guardian says she died two days after falling ill. A local state television station, as cited by the AP, reported that she died in a hospital in Shelekhov, a town just outside Irkutsk.

The plague fear grew out of unconfirmed reports. Lyudi Baikala, citing sources it did not name, reported that she broke a test tube holding the pneumonic plague pathogen on September 25 and soon fell ill, and that starting Thursday, FSB security patrols escorted ambulances carrying her contacts to testing. Russian authorities have not confirmed that account. Rospotrebnadzor, the national health watchdog, says its probe found “no incidents involving the handling of pathogenic microorganisms,” NBC reports, and Irkutsk Governor Igor Kobzev said on Monday that tests found no microorganisms linked to her work in her body. Anna Popova, the head of Rospotrebnadzor, flew to Irkutsk on Friday and met regional officials, the AP reports.

The steps on the ground drew as much attention as the death itself. Shelekhov’s mayor, Maxim Modin, said on Friday that the town’s hospital had stopped admitting or discharging patients under quarantine and that its laboratory had halted routine tests, according to the AP. Russian media put the number of contacts under medical observation at nearly 200. A relative of an institute employee told Siberia.Realities: “They locked everyone inside for isolation starting Friday (October 2), more than 60 people.” The Guardian, citing Russian media, says those colleagues slept on floors and chairs while tests ran, and that similar rules covered five hospitals, where relatives could not visit patients. On Tuesday, the Irkutsk branch of Rospotrebnadzor denied what it called “fake” reports of an enhanced sanitary regime across the region, NBC reports, and DW reports that the national watchdog called such claims “untrue.”

Russia’s own numbers do not line up neatly. In a note sent through the international health alert system and relayed to the AP by the WHO, Russian officials said on Tuesday: “Test results showed no presence of dangerous infectious disease pathogens in any of the contacts.” The same note said medical monitoring had ended for every contact. Rospotrebnadzor said its tests turned up only common infections. “Laboratory testing identified two cases of Covid-19 and two cases of rhinovirus infection,” it said, as quoted by NBC News, and Reuters quoted it saying: “None of the contacts showed any changes in their state of health associated with infectious disease.” Yet NBC also reported on Tuesday that officials had tested 60% of the identified group so far, and Elena Sofina, a deputy head of the Shelekhov district, told Reuters that authorities had released 60% of those quarantined. This desk could not reconcile 60% with 100%; the figures may describe different groups or different moments in the day.

The WHO says it asked Russia on Saturday about the laboratory tests under way, the reason for the contact tracing, and the health of the people traced, Healthbeat reports. Russia answered on Tuesday that no case of plague had turned up in Irkutsk. “According to the authorities, the woman’s illness initially presented as a typical acute respiratory viral infection,” WHO spokesman Christian Lindmeier said, according to the AP. Reuters could not immediately establish whether that answer ruled out plague in the technician herself. The agency rates the risk “moderate to low” for Irkutsk, “low” for the rest of Russia, and “very low” for Europe, the Guardian reports; the AP cites a “very low” risk outside Russia. Lindmeier said Russia had not asked the WHO to send experts. Then, late Tuesday, Tedros wrote on X that the WHO had asked Russia to clarify three things: the cause of the woman’s severe pneumonia, the pathogen that prompted the public health measures, and the reports of a second employee with pneumonia of undetermined cause. He called for timely, complete, and transparent information sharing under the International Health Regulations. Rospotrebnadzor, for its part, said it had recorded no infectious disease among the institute’s staff over the past 10 days, according to Reuters.

Washington moved on several tracks at once. Asked whether he had spoken with Putin, Trump said, “I have a call scheduled, yes,” and added that it would come “very soon,” the Guardian reports. Asked what U.S. intelligence had learned, he said the United States had entered “very deep discussions” on the case and would have more to report “probably tomorrow,” according to the AP. On Monday he had offered help: “I hate to see them having it. We’ll help. Everybody who has that kind of a problem, we’ll always help.” He also said that “somehow those microbes have gotten stronger and smarter.” Speaking at a news conference in Reykjavik, Iceland, Rubio described Russian information sharing so far as “quite limited, but hopefully that will change in the next few hours and days,” the AP reports. A State Department spokesperson told CNN: “We encourage Russian authorities to share accurate information quickly and openly.” The Centers for Disease Control and Prevention described itself on X as “working across the U.S. government to assess developments as additional information becomes available” and said it saw no indication of a broader threat to the United States.

Reports differ on how far the diplomatic pressure has gone. The Wall Street Journal, in a story posted at 3:52 p.m. ET (12:52 p.m. PT), reported that the State Department had sent Moscow a démarche, a formal diplomatic communication, warning that a failure to disclose details runs counter to Russia’s international health obligations; the Guardian repeats that report. CNN, citing one source, reported that the United States had considered issuing a démarche, and a Washington Post headline describes the department as preparing a formal request. CNN also reported that U.S. officials had sought details on whether anyone had modified the pathogen, and it quoted one unnamed U.S. official: “We don’t know a lot right now about what actually happened.” According to CNN, the administration has not imposed any new travel restrictions; the State Department already tells Americans not to travel to Russia for any reason.

Moscow has answered with calm words and one jab. Kremlin spokesman Dmitry Peskov told the public to follow Rospotrebnadzor rather than “rumors or speculation,” and when reporters asked whether the worker’s lab results would come out or whether doctors had performed an autopsy, he deferred to the watchdog: “Rospotrebnadzor provides comprehensive information,” NBC reports. He welcomed Trump’s offer of help without saying whether Russia would accept it, Reuters reports. Rospotrebnadzor then offered to help the United States, the Guardian reports, saying “the situation regarding dangerous infectious diseases remains unstable” there and pointing to a “significantly worsened” measles situation in three U.S. states and a “fatal case of plague” in New Mexico in June. In Shelekhov, residents told Reuters that daily life had barely changed. “Everyone had face masks at home and wore them for no more than 24 hours,” said a woman who gave her name only as Anna.

Outside experts split between calm and suspicion. Pneumonic plague, the lung form of the disease, can spread from person to person through respiratory droplets, and the WHO says it can kill if left untreated for 18 to 24 hours after the first symptoms, Healthbeat reports; with prompt antibiotics, recovery rates run high. Dr. Glenn Wortmann of MedStar Washington Hospital Center told the AP that the bacteria do not “travel very far.” Others point to history. In 1979 Soviet officials blamed bad meat for a deadly anthrax outbreak in Sverdlovsk; in 1992 President Boris Yeltsin acknowledged that it came from military bioweapons research, Healthbeat notes. Dr. Ashish Jha, who coordinated the Biden White House’s Covid-19 response, wrote on X: “We need to understand exactly what has happened. And we have to assume we may not know the full truth.” Jennifer Nuzzo, who directs the Pandemic Center at Brown University’s School of Public Health, told CNN that measles outbreaks already strain U.S. public health: “God forbid you layer another pathogen onto the already laborious and difficult work of going after measles.” Healthbeat says it has seen no evidence that the death involved any bioweapons program.

The call with Putin would come with other business on the table. The AP notes that the administration faces an October 18 deadline to decide which Russian entities, if any, to sanction under the Lindsey O. Graham Sanctioning Russia and Iran Act, which Trump signed into law on September 18. As of about 7 p.m. PT on Tuesday, this desk had seen no report that the Trump–Putin call had taken place, no Russian statement naming the pathogen behind the woman’s pneumonia, and no public answer about the reported second sick employee.